WSX-1 plays a significant role for the initiation of experimental autoimmune uveitis
نویسندگان
چکیده
منابع مشابه
The complement system plays a critical role in the development of experimental autoimmune anterior uveitis.
PURPOSE The role of complement in ocular autoimmunity was explored in a experimental autoimmune anterior uveitis (EAAU) animal model. METHODS EAAU was induced in Lewis rats by immunization with bovine melanin-associated antigen. Complement activation in the eye was monitored by Western blot for iC3b. The importance of complement to the development of EAAU was studied by comparing the course o...
متن کاملSLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU)
PURPOSE SWAP 70-like adaptor of T cells (SLAT; aka Def6) is a recently discovered guanine nucleotide exchange factor for Rho guanosine triphosphate (GTP)ases that has been previously shown to play a role in cluster of differentiation(CD)4+ T cell activation, T-helper (Th)1/Th2/Th17 differentiation and development of experimental autoimmune encephalomyelitis. Here, we investigated the role of SL...
متن کاملKey role for IL-21 in experimental autoimmune uveitis.
IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas IL-2 promotes development of regulatory T cells and confers protection from autoimmune disease, IL-21 promotes differentiation of Th17 ce...
متن کاملAnti-inflammatory role of IL-17 in experimental autoimmune uveitis.
Previous studies have shown that IL-17 is a strong proinflammatory cytokine and that IL-17-producing autoreactive T cells play a major role in the pathogenesis of autoimmune diseases. In a previous study, we showed that injection of experimental autoimmune uveitis-susceptible mice with anti-IL-17 Abs blocked subsequent disease development. To determine whether administration of IL-17 to experim...
متن کاملMouse models of experimental autoimmune uveitis.
The mouse model of experimental autoimmune uveitis, induced by immunization of mice with the retinal protein IRBP, was developed in our laboratory 20 years ago and published in 1988. Since that time it has been adopted by many investigators and has given rise to many studies that helped elucidate genetic influences, dissect the basic mechanisms of pathogenesis and test novel immunotherapeutic p...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2006
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxl125